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A Comparing Study of Clarithromycin XL and Co-amoxiclav for Treatment of Chronic Sinusitis
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Amini M *   , Yarmohammadi ME |
| , mamini55602@yahoo.com |
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Abstract: (13423 Views) |
| Background and Aim: chronic sinusitis is one of the most common medical problems and affected annually 30 million people in USA. This study the efficacy and safety of clarithromycin XL and Co-amoxiclove on clinical and CT scan finding in patients suffering from chronic sinusitis were compared. Material and methods: In this clinical trial a total of 59 subjects (62.7% male, 37.3% female, mean age 28 years) with clinical symptoms and CT scan findings of chronic sinusitis were divided into two groups and treated with clarithromycin XL or Co-amoxiclav. Results: clinical success rates at the end of therapy similar in two groups, but in subjects treated with clarithromycin XL, CT scan findings had a better results than Co-amoxiclav group (53% versus 29%). Gastrointestinal discomfort was the most frequent treatment–related adverse effects, but no significant difference in two groups. Conclusion: Results demonstrated that clinical success rate of clarithromycin XL and Co-amoxiclav, was similar for treatment of chronic sinusitis, but clarithromycin XL was more effective in improvement of CT scan findings. |
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| Keywords: Chronic Sinusitis, Chronic Rhinosinusitis, Clarithromycin, Co-amoxiclav |
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Full-Text [PDF 199 kb]
(9870 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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