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pajoohande 2010, 15(1): 1-6 Back to browse issues page
Investigating the Therapeutic Effect of Bee Venom on Polycystic Ovarian Syndrome in Rats
Homa Mohseni Kouchesfahani *, Mohammad Nabyooni, Hamed Adham
, kouchesfehani@yahoo.com
Abstract:   (10937 Views)
Background and Aim: Polycystic ovarian syndrome (PCOS) is the most frequent endocrine disorders in women affecting 5-10% of women of reproductive age with abnormal cycles and hyperandrogenism. This syndrome represents an autoimmune disease that demonstrates high concentration of antiovarian antibodies. Bee venom with its immune reaction and its anti-inflammatory–like action works 100 times stronger than hydrocortisone. The aim of this study was to investigate the therapeutic effect of bee venom on the polycystic ovarian syndrome in rats. Materials and Methods: The induction of PCOS was achieved by subcutaneous single injection of 2mg Estradiol valerate (EV) dissolved in sesame oil in estrous phase of ovarian cycle adult wistar rat. Sixty days after EV treatment 0.2mg/kg body weight of bee venom were injected intraperitoneally for 10 days. Rats were sacrificed and ovaries were removed to evaluate histopathological and histomorphometrical changes in EV- induced PCOS, bee venom treatment and normal intact animals. The tissues were processed routinely, paraffin blocks were made and 6-7 micron were prepared and stained with hematoxylin & eosin. Results: Thickness of granuloza layer, theca, number and diameter of cysts and number of atretic follicles were measured and showed a significant improvement (p<0.05) in indicated parameters in bee venom treated rats. Moreover, in more than 70% of cases, corpus luteum was observed in bee venom treated ovary, the condition that didn't observe in PCOS, indicating re- ovulation. Conclusion: Bee venom is a new approach for induction of ovulation in patients with resistant polycystic ovarian disease. It is safe, easy to use, and lacks major side effects.
Keywords: Polycystic Ovary Syndrome, Hyperandrogenism, Bee venom, Estradiol valerate, Atretic follicles, Corpus luteum.
Full-Text [PDF 198 kb]   (2673 Downloads)    
Type of Study: Original | Subject: Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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Homa Mohseni Kouchesfahani, Mohammad Nabyooni, Hamed Adham. Investigating the Therapeutic Effect of Bee Venom on Polycystic Ovarian Syndrome in Rats. pajoohande. 2010; 15 (1) :1-6
URL: http://pajoohande.sbmu.ac.ir/article-1-868-en.html

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