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Comparative evaluation of the OST and SCORE for prediction of osteoporosis in post menopausal women
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Arman Ahmadzadeh   , Alireza Rajaee * , Somayeh Rezaian , Farshad Tojari , Mohammad Mehdi Emam , Mohammad Moslemizadeh |
| , somaye.rezaian@gmail.com |
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Abstract: (11959 Views) |
| Background and Aim: There are many risk factors for osteoporosis which can help to decide whether a person needs bone densitometry or not. For reducing the cost of mass screening of osteoporosis, numerous risk assessment methods have been created, from which Simple Calculated Osteoporosis Risk Estimation (SCORE), Osteoporosis Risk Assessment Instrument and Osteoporosis Self Assessment Tool (OST) are the most recognized ones. The objective of this study was to compare SCORE and OST in osteoporotic and high risk women. Materials and Methods: SCORE and OST were calculated for 210 postmenopausal women in Loghman Hospital. After bone densitometry the women were categorized as healthy, osteoporotic (T-score< -2.5), or high risk (T-score<-2). The sensitivity, specificity, predictive value, likelihood ratio (LR), positive predictive value (PPV) and negative predictive value (NPV) of the tests were determined. Then their true positive, true negative, false positive and false negative were assessed by chi2 test. Results: The mean age of the patients was 57.3 y. 43 (20.3%) had osteoporosis and 88 (41.7%) were at risk. The PPV and NPV of OST was 39.2% and 91.6%, respectively, while they were 34.2% and 97.8% for SCORE, respectively. The sensitivity of SCORE was higher in osteoporotic and high risk women (95% and 88.2%, respectively). In addition, it’s NPV and diagnostic odds ratio was higher. The specificity of OST was higher in osteoporotic and high risk women (71.4% and 75.4%, respectively). In addition, it’s LR was higher. Conclusion: Considering the area under the curve for ROC in 95% CI, the difference between two methods was not statistically significant however, SCORE can exclude low risk population with higher sensitivity and NPV, while OST is useful for detecting high risk population with its better specificity and PPV. |
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| Keywords: Risk Assessment, Osteoporosis, SCORE, OST, Mass Screening |
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Full-Text [PDF 200 kb]
(4020 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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