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Correlation between ER, PR, HER2 receptors and prognostic factors in breast cancer
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Hamid-Reza Mirzaei   , Afsaneh Sabahat , Fatemeh Nasrollahi * , Ladan Mohammadi-Yeganeh |
| , n.fatemeh@ yahoo.com |
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Abstract: (12294 Views) |
| Background and Aim: Studies have shown that breast cancer patients who have estrogen receptor (ER) or progesterone receptor (PR) positive tumors have lower risks of mortality and better response to treatment compared to women with ER and/ or PR negative breast tumors. However, few studies have been performed about these factors and their relation with demographic or clinical characteristics in Iran. So we decided to evaluate the correlation between ER, PR and Human epidermal growth factor 2 (HER-2) with age, tumor size, tumor histological grade and lymph node metastasis as prognostic factors in breast cancer. Materials and Methods: In this cross sectional study, 138 patients with invasive ductal breast carcinoma who were admitted in Shohadaye Tajrish hospital during 2004-2005 were studied and all information was gathered from patients’ medical records. Results: Statistically significant correlation between ER, PR, and HER-2 receptors with age, tumor size and lymph node metastasis was not observed. Also correlation between ER, PR and HER-2 receptors with tumor grade was not significant. But there was significant correlation between HER-2 receptors and tumor grade (P<0/05). Correlation between ER and PR with HER-2 receptors was not significant. Also there was not a significant correlation between Triple Negative tumors and age, tumor size, tumor grade, and lymph node involvement. Conclusion: It seems that patients with HER2 positive tumors tend to face higher grade tumors and metastasis besides, maybe they face an increased risk of mortality. |
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| Keywords: Receptors, Progesterone, Receptors, Estrogen, HER2 Receptors, Breast Neoplasms, Prognostic Factors |
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Full-Text [PDF 158 kb]
(6213 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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