Background and Aim: Myocardial infarction continues to be a major public health problem in many countries. Given the disparity of outcome in different studies and its importance, we evaluated the outcome of patients with ST segment elevated myocardial infarction (STEMI) and its influencing factors in Loghman hospital. Material and Methods: This longitudinal study conducted between 2007-2008. All patients with STEMI admitted in Loghman hospital were included. The subjects were followed up for 30 days concerning their vitality status. TIMI risk score, demographic and clinical factors were also determined and their association with death was evaluated. Results: Totally, 85 patients with a mean age of 58±14 years were evaluated, of whom 67% were males. Death occurred in 21.2%. Among died subjects, 77.8% had TIMI score of at least 8 when compared to 7.5% of alive patients (p<0.005). Sex, history of diabetes mellitus, smoking, angina and family history of coronary disease had no effect on mortality. Totally, 61% of patients who died didn’t receive streptokinase vs. 22.4% in alive subjects (p<0.005). Conclusion: Our measured survival rate is acceptable and TIMI risk score is a useful tool in predicting outcome of patients with STEMI.