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Comparing the Serum Level of Apelin in Patients with Lone Atrial Fibrillation and their Control Group
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Mohammad Asadpour Piranfar *   , Amir Hamzeh Pardal , Maryam Afshar , Mohammadreza Beyranvand |
| , drpiranfar@yahoo.com |
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Abstract: (14535 Views) |
| Background and Aim: Atrial fibrillation (AF) is one of the most common arrhythmia and is a risk factor for stroke and heart failure. Apelin is a protein with multiple effects on cardiovascular system such as: endothelium-dependent vasodilation, positive inotropy, declining ventricular preload and after-load and increases cardiac contractility. Plasma level of Apelin is a practical tool for evaluating the severity of heart failure, however, it could be a good prognostic factor in Lone AF. Material and methods: In this case-control study, 26 patients with Lone AF and 27 age- and sex- matched controls were enrolled. Meanwhile, the following exclusion criteria were applied at baseline: cardiomyopathy, congestive heart failure, hyperthyroidism, hypertension, coronary artery disease, valvular heart disease, and rheumatic heart disease. Then, 3cc citrated venous blood was obtained and Apelin plasma level was measured with ELISA technique. Results: The study population included 17 males and 9 females with the mean age of 53.1±12.4 years in the LAF and 16 males and 11 females with the mean age of 51.8±8.3 years in the control group. Level of Apelin was not significantly differed between LAF and control group. However, patients aged ≥60 years had significantly lower Apelin level when compared with those younger 60 years. Furthermore, gender did not influence the level of Apelin in LAF and control group. Conclusion: Results revealed no reduction in Apelin level of Lone AF group aged <60 years old, but there was a significant reduction in Apelin level among patients aged ≥60 years. Hence, Apelin level determination is of low benefit in patients aged <60 years. |
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| Keywords: Lone atrial fibrillation, Arrhythmia, Apeline. |
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Full-Text [PDF 99 kb]
(3376 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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