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Evaluating the Serum Level of Xanthine Oxidasein Patients with Lone Atrial Fibrillation
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Mohammad Asadpour Piranfar *   , Amir Hamzeh Pardal , Mohammad Aghajani , Mohammadreza Beyranvand , Manouchehr Behnia , Mohammad Esmail Gheydari , Marzieh Khayyatzadeh |
| , drpiranfar@yahoo.com |
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Abstract: (13623 Views) |
| Background and Aim: Atrial fibrillation is one of the most common arrhythmia and is a risk factor for stroke and heart failure. Prior investigators have proposed relationship between reactive oxygen species and their enzymatic source such as xanthine oxidase. In this study, we compare the level of serum xanthine oxidase in patients with lone atrial fibrillation (LAF) and control group. Materials and Methods: In this case–control study, 26 LAF patients without any other important disease such as CHF, cardiomyopathy, hypertension, CAD, valvular heart disease, and rheumatic heart disease, as well as 27 age- and sex-matched controls were enrolled. Serum xanthine oxidase was measured by xanthine oxidase assay kit. Finally, chi square and Mann-Whitney were used for data analysis. Results: The study population included 26 patients and 27 controls with the mean age of 49.7±12.4 and 53.1±11.1 years, respectively. The mean serum level of xanthine oxidase was 13.40±7.53 U/L in patients and 9.70±6.40 U/L in controls. Conclusion: Results revealed significant elevation in xanthine oxidase level in lone AF group. This elevation was more significant in older patients. Therefore, the inhibition and control of the enzyme level could be important in lone AF patients. Perhaps it would decrease cellular changes and prevent recurrence of the AF and its complication. |
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| Keywords: Lone atrial fibrillation, Arrhythmia, Xantine Oxidase |
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Full-Text [PDF 104 kb]
(3801 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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