Background: A healthy normal skin is essential for a person's physical and mental well being. Disability originated from skin diseases is important in daily life. The present study is assessed health related quality of life in dermatologic patient on autumn 2006. Materials and Methods: This study was performed on 532 outpatient dermatologic clients by Persian version of SF-36 questionnaire. Data were analyzed by SPSS-13 software. The statistical significance of the observed differences was tested with parametric (t-test, ANOVA and Pearson’s correlation) and non-parametric tests (Mann-Whitney, Kruskall-Wallis and Spearman’s correlation). Results: Mean age of participants was 33.8±15 and gender of them was 32.5% male and 67.5% female. The mean scores on all SF-36 subscales reported by the participants on this study were considerably lower than the Iranian national norms. Moreover, scores of married participants was lower than singles. Conclusion: Data of the present study reveal one major issue. There is no correlation between the scores in subscales of SF- 36 questionnaire & severity, width and history of hospital admission from dermatologic disease but there is significant correlation with location of lesion.