Background: Myocardial infarction (MI) is one of the most common causes of morbidity and mortality with an increasing prevalence. There has been no documented report on the long-term outcomes of patients with MI in Iran. Materials and Methods: Patients who were discharged from Loghman hospital in a one-year period (November 2003-2004) were enrolled in this cohort study. They were called for a follow-up visit one year after discharge and outcome measures including: rehospitalization, current medications, coronary anatomy appearance in angiography, percutaneous coronary interventions, coronary artery bypass graft surgery, cerebrovascular accidents and mortality were assessed. Results: 132 studied patients (76.5% male) with a mean age of 59.2 ± 13.1 years enrolled in this study. Type of MI was non ST-elevated MI (NSTEMI) in 20.5% and ST-elevated MI (STEMI) in 79.5%. Only 58.1% of patients with STEMI received thrombolytic therapy. Reasons for withholding thrombolytic therapy were: patient delay in 26 (24.8%), contraindications in 10 (9.5%) physician error in 8 (7.6%). Coronary angiography was performed in 56 (90.3%) of candidates. Revascularization (PCI or CABG) was recommended to 39.4% of patients. Rehospitalization was needed in 14.3% of patients during the one-year follow-up. Eight patients (6.1%) had died, all of whom were male and aged over 60. Compliance with the administered drug regimen was 98.5% for Aspirin, 74.2% for β-blockers, 71.2% for ACEI and 67.4% for Statins. Conclusion: Patients with MI can be followed with a satisfactory compliance in long-term. Our mortality rate was relatively low, but further studies are warranted to address the reasons for it and its risk factors.