Abstract:

Background and Aim: Today induced pluripotent stem cells (iPS) have been recognized as a new and good cell source for cell therapy. In recent years, research in the field of cell therapy and tissue engineering is widely developed. Today there is a potential for the preparation of various types of scaffolds for different cells. In this study, in order to increase surface adhesion properties and cell survival, using of suitable concentration of gelatin modified nanofiber scaffold polylactic acid.

Materials and Methods: Different scaffolds were fabricated by an electrospinning technique and cells morphology and cells viability were evaluated by using a scanning electron microscopy and MTT assay respectively.

Results: The results of this study demonstrated that the modified PLA/gelatin scaffold is a more appropriate model for the adhesion, proliferation and cell survival of iPS cells. PLA/gelatin scaffold cause significantly increases in cell attention and cell survival.

&zwjConclusion: These findings are an important step in the use of appropriate three dimensional culture in order to treat a variety of diseases.