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Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity in Tehran Lipid Glucose Study population
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Kobra Sharifi   , Fereidon Azizi , Fatemeh Rostami , Maryam sadat Daneshpour , Mehdi Hedayati * |
| PhD in Biochemistry, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , hedayati@endocrine.ac.ir |
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Abstract: (13430 Views) |
| Background and Aim: Tumor necrosis factor-α (TNF-α) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Therefore, we examined the relationship between the G-308A and G-238A polymorphisms of TNF-α gene promoter variants and obesity in an Iranian population. Materials and Methods: Subjects of the Tehran Lipid and Glucose Study classified into two age groups under and above 18. Adults classified in three groups according to their body mass index and less than 18 years old subjects classified in two groups (under 85th percentile for their age and sex and above 85th percentile). 244 persons were selected to examine -308 site and 239 persons were selected to examine -238 site. The mentioned polymorphisms were examined with PCR and RFLP methods. Results: The allele frequency of TNF-α polymorphism was in the Hardy Weinberg equilibrium and there was no relation between BMI and the frequency of this allele. Conclusion No association between G-308A and G-238A TNF-α promoter polymorphisms and obesity could probably indicate that it is not an important risk factor for obesity and consequently for cardiovascular disease. |
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| Keywords: Obesity, Tumor necrosis factor alpha, BMI, Polymorphism |
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Full-Text [PDF 130 kb]
(2959 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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