[Home ] [Archive]    
:: Volume 12, Issue 4 (october- november 2007) ::
pajoohande 2007, 12(4): 293-297 Back to browse issues page
Efficacy of Oral Naltrexone in Treatment of Pruritus in Patients with Eczema
Malekzad F *, Arbabi M, Tousi P, Mohtasham N, Mohajer M, Jaberian M
, f-malekzad @yahoo.com
Abstract:   (11552 Views)
Background: Regarding to the role of opioid receptors in peripheral cutaneous sensations and central itch procession, this study was designed to determine the efficacy of oral Naltrexone in the treatment of pruritus in patients with eczema in comparison with placebo. Materials and Methods: Thirty eight patients with eczema complaining of pruritus were studied. Pruritus scores were evaluated. Patients were given the placebo (n=20) or Nalterxone 50 mg (n=18) for a two-week period. During the study, pruritus scores were distinguished by a visual analogue scale (VAS) system and recorded in patients questionnaires three times, at the start of study, after 1 week, and after 2 weeks Results: In the both groups VAS score were decreased, although Naltrexon was more effective than placebo in decreasing the VAS scores, both in 1st week week (P < 0.005) and 2nd week (P< 0.001). Adverse events (mainly nausea and sedation were observed in 3 patients (2 in Naltrexon group and 1 in placebo group) Conclusion: Naltrexone is more effective than placebo in treatment of pruritus in patient affected with eczema. Naltrexone might be considered as an adjuvant remedy in treatment of pruritus.
Keywords: Naltrexone, Eczema, Pruritus
Full-Text [PDF 61 kb]   (2861 Downloads)    
Type of Study: Original | Subject: Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Malekzad F, Arbabi M, Tousi P, Mohtasham N, Mohajer M, Jaberian M. Efficacy of Oral Naltrexone in Treatment of Pruritus in Patients with Eczema. pajoohande. 2007; 12 (4) :293-297
URL: http://pajoohande.sbmu.ac.ir/article-1-590-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 4 (october- november 2007) Back to browse issues page
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 4414