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Background: Oxidative stress and lipid abnormalities are two major risk factors for development of atherosclerosis among hemodialyzed patients. Administrating of Lipid-normalising agents, solely or in combination together, can not correct all lipid abnormalities in hemodialyzed patients. The present study, therefore, was desinged to evaluate the effects of combination therapy of vitamin E and tolerable doses of nicotinic acid on serum lipids and apoproteins in hypertriglyceridemic hemodialyzed patients. Materials and Methods: The study was a double-blind randomized clinical trial. Thirty-nine hemodialyzed patients with fasting triglyceride range between 230 and 500 mg/dl were randomly assigned into three groups, receiving combination of vitamin E (600mg/d) and nicotinic acid (500mg/d), nicotinic acid alone (500mg/d), and placebo, respectively. All patients received their supplements for 13 weeks. The blood samples were collected after a 12 to 14-hour duration of fasting at the beginning of the study, followed by other samplings performed at the end of sixth and thirteenth weeks, respectively, and serum lipids and apoproteins were measured.accordingly. Results: During the study, the mean serum triglyceride level was significantly reduced in the group receiving combination therapy of vitamin E and nicotinic acid, compared to the placebo group. Compared to that of placebo group, mean serum HDL-C levels were significantly increased two groups of combination therapy, and nicotinic acid alone, although LDL-C/HDL-C ratios were significantly decreased. There was no significant difference in the means of total cholesterol of serum, LDL-C , apoAI , apoB100 and Lp(a) between three groups. Conclusion: It is concluded that combination therapy of vitamin E and nicotinic acid in hypertriglyceridemic hemodialyzed patients can result in improvement in almost every lipid abnormalities, but except high levels of Lp(a).

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Background and Aim: One of the most effective factors contributing to sperm dysfunction and reducing the sperm motility is increasing the reactive oxygen species (ROS) and oxidative stress of seminal plasma. The aim of the present study was to investigate the effects of combined docosahexaenoic acid (DHA) and vitamin E supplements on oxidative stress markers in seminal plasma in asthenozoospermic men. Materials and Methods: In this randomized, triple-blind, placebo-controlled clinical trial, out of 275 men who referred to Avicenna infertility clinic, fifty asthenozoospermic males, defined as less than 50% sperm motility or less than 25% with rapid progressive motility. They were randomly assigned to one of two groups according to the stratified blocked randomization. Participants in the intervention group took daily 465 mg of DHA and 600 IU of vitamin E and those in the control group took daily two placebos for 12 weeks. 8-isoprostane, total antioxiant capacity (TAC), and malondialdehyde (MDA) concentrations, sperm characteristics, dietary intakes, anthropometric measurements and physical activity were measured at the baseline and at the end of the study. Statistical analyses were performed using the SPSS software. The statistical tests were analyzed of covariance, student's t-test, paired-samples t-test, Wilcoxon and Mann-Whitney. Results: Out of 50 participants, 22 men in the intervention group and 20 men in the control group completed the protocol of the study. TAC concentration of seminal plasma significantly increased in the intervention group, as compared with the control values (P<0.001). 8-isoprostane (P=0.033) and MDA (P=0.002) concentration of seminal plasma significantly decreased in the intervention group, as compared with the control values. ‍Conclusion: According to this research, combined DHA and vitamin E supplements led to decreasing oxidative stress of seminal plasma. Because of the effects of ROS on sperm dysfunction, intakes of antioxidants such as vitamin E may reduce oxidative stress in infertile men.