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pajoohande 2016, 20(6): 308-314 Back to browse issues page
Protective effect of broccoli sprouts powder against metabolic fructose-induced metabolic disorders in rats
Mahshid Abd-Mishani, Zahra Bahadoran, Hanieh-Sadat Ejtahed, Parvin Mirmiran *, Fereidoun Azizi
, mirmiran@endocrine.ac.ir
Abstract:   (3937 Views)


Background and Aim: In this study, we aimed to investigate whether a diet rich in high-sulforaphane broccoli sprouts powder (BSP) could attenuate metabolic abnormalities induced by high-fructose corn syrup (HFCS).

Materials and Methods: Forty-eight male wistar rats with similar average body weight (253±23g) were randomly allocated into four groups: Baseline control, control (C) (normal diet), fructose (F) (normal diet + water containing 30% fructose), and fructose + BSP (F+B) (diet with 5% BSP + water containing 30% fructose), and followed for 8 weeks. Biochemical measurements including fasting serum triglyceride levels, total cholesterol, HDL-C, alkaline phosphatase, gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase were assessed at baseline, and the fourth and eighth weeks.

Results: The mean change of body weight was 31.5%, 31.4% and 18.3% in the C, F, and F+B groups, respectively; the mean weight gain of group F+B was lower than those of the other groups (p=0.009). A significant increasing trend was observed in serum total cholesterol, triglycerides and LDL-C levels in group F during the intervention (p<0.05). Serum alkaline phosphatase and gamma-glutamyl transferase also showed a significant increasing trend in group F (p<0.05). After 8-weeks of intervention, in group F+B, LDL-C was significantly lower (p=0.001) and HDL-C was significantly higher (p=0.048) than the other groups.

Conclusion: High-sulforaphane broccoli sprouts could have favorable effects against metabolic disorders-induced by a high fructose diet.

Keywords: Keywords: Broccoli sprout, Sulforaphane, High-fructose corn syrup, Metabolic disorders
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Type of Study: Original | Subject: Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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Abd-Mishani M, Bahadoran Z, Ejtahed H, Mirmiran P, Azizi F. Protective effect of broccoli sprouts powder against metabolic fructose-induced metabolic disorders in rats . pajoohande. 2016; 20 (6) :308-314
URL: http://pajoohande.sbmu.ac.ir/article-1-2095-en.html

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