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Assessment of demographic, clinical and laboratory status of patients with thalassemia major and intermedia referred to thalassemia research center in Sari, Iran, during 2007- 2009
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Hossein Karami *   , Mehrnoosh Kowsaryan , Kourosh Vahidshahi , Hasan Karami , Soheila Shahmohammadi , Mohammadreza Mahdavi , Mohammad Bagher Hashemi , Elaheh Yousefi Abdolmaleki , Motahareh Majdi , Mahdei Ahangar |
| , hokarami@mazums.ac.ir |
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Abstract: (12896 Views) |
| Background and Aim: Mazandaran province has the highest patient population ratio for thalassemia major in the country (1 to 1000) and 11% of people living in Mazandaran province carry the disease gene. This study was performed to identify the clinical and laboratory status of the thalassemia patients referred to the largest therapeutic center of Mazandaran province. Materials and Methods: This cross sectional study was performed by reviewing of the patients' documents from May 2007 until May 2009. Demographic and clinical characteristics were extracted and analyzed by SPSS11, using descriptive statistics. Results: From 1010 patients' records, 53% were male. 84.2% of patients had thalassemia major and 15.8% had thalassemia intermedia. Mean age of patients was 23±8 years. 93 patients were married and 60 had children. The average of three last ferritin measurements was 1000-2000 in about 40% of the patients 22% patients had ferritin level more than 3000. Cardiac MRI T2 was performed in 160 patients and 34% had severe iron storage. 81 patients (8%) had diabetes mellitus and age of diagnosis was 20 ± 7 years. 28 patients were treated for heart failure. Hepatitis C infection occurred in 73 patients. Each month, 23,000 deferoxamine vial and 12,000 deferiprone tablets were used. Thirty patients received free Osveral. Conclusion: The age distribution of the patients indicates that prenatal screening has been successful. On the other hand, increased life expectancy of patients was due to medical care. Most of the patients are continuing their physical growth. So their need for blood and iron chalator drugs is increasing in following years. |
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| Keywords: Beta-Thalassemia, Thalassemia Major, Thalassemia intermedia, Genetic Testing, Mazandaran, Iran |
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Full-Text [PDF 251 kb]
(2080 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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