Background and Aim: Basal cell carcinoma (BCC) is the most common skin cancer. Photodynamic therapy (PDT), as a novel, non-invasive therapeutic approach, may be considered a valuable strategy. This study was designed to evaluate the efficacy of PDT in treatment of BCC. Materials and Methods: This clinical trial was achieved on 28 BCCs from 12 patients. Patients were treated with PDT monthly for 1-6 sessions and evaluated for clinical response, cosmetic results and probable side effects. Results: The study was achieved on 28 lesions from 12 patients. Complete response was achieved in 9 (32.1%) lesions (p<0.05). Patients who were younger (p<0.01) and those with smaller lesions (p<0.001) showed more complete response. Superficial BCC had also significant higher complete response rate (p<0.01). Complete response rate was lower in patients with positive history of radiotherapy for tinea capitis in childhood (p<0.05). Conclusion: PDT would be a good therapeutic approach in patients with BCC, especially superficial type. It is associated with high efficacy rate and low side effect.