:: Volume 19, Issue 4 (September & October 2014) ::
pajoohande 2014, 19(4): 184-188 Back to browse issues page
Evaluation of the role of serum progesterone level on the day of human chorionic gonadotropin administration on intracytoplasmic sperm injection outcome
Marzieh Mehrafza *, Azadeh Raoufi, Talieh Rahimian, Zahra Nikpouri, Mehrsha Nasrollahzadeh, Parvaneh Abdollahian, Ahmad Hosseini
Infertility Research Center, Mehr Medical Institute, Rasht, Iran; Phone: +98 0131 7764270, Fax: +98 0131 7764257; , dr.mehrafza@yahoo.com
Abstract:   (3532 Views)
Background and Aim: According to some literature on the importance of progesterone on prognosis of controlled ovarian hyperstimulation outcome, the present study was designed to evaluate the role of elevated serum progesterone level on the day of hCG administration on ICSI results. Materials and Methods: In the present descriptive study, 224 patients undergoing ICSI with GnRH agonist were analyzed. These patients were divided into 2 groups based on serum progesterone level on the day of hCG administration: progesterone <1 ng/ml (group 1, n=180), progesterone ≥1 ng/ml (group 2, n=44). Baseline and stimulation characteristics of patients were compared between groups. Results: The mean age, BMI, basal LH, FSH and E2 levels did not differ between two groups. Estradiol level on the day of hCG (1951.5±800.7 vs. 1232±734.6, P<0.001) and number of retrieved (14.6±7.6 vs. 9.9±6, P<0.001) and MII oocytes (11.8±5.9 vs. 8.1±5.3, P<0.001) were significantly higher in group 2 than group 1. The stimulation days (12.9±1.8 vs. 13±1.8, P=0.767), total number of gonadotropin ampoules (40.6±16 vs. 43.6±12.9, P=0.236), fertilization rate (59.7% vs. 54.1%, p=0.068) and mean number of embryos transferred (2.8±0.8 vs. 3±0.6, P=0.086) were not significantly different between groups. No significant decrease in implantation (14.3% vs. 20.2%, P=0.128) and clinical pregnancy rate (29.5% vs. 45%, P=0.063) was identified in group 2 as compared with group 1. Conclusion: It seems that elevated serum progesterone level on the day of hCG administration is effective on prognosis of ICSI outcome.
Keywords: Progesterone/sperm injections, Intracytoplasmic/chorionic gonadotropin
Full-Text [PDF 468 kb]   (1131 Downloads)    
Type of Study: Original | Subject: Medicine
Received: 2014/12/10 | Accepted: 2014/12/10 | Published: 2014/12/10


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Volume 19, Issue 4 (September & October 2014) Back to browse issues page