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:: Volume 19, Issue 2 (خرداد و تیر 2014) ::
pajoohande 2014, 19(2): 86-90 Back to browse issues page
Sensitivity and specificity of serum PSA, free to total PSA ratio and transrectal ultrasonography findings in prostate cancer detection
Mansoor Jamali Zawarei , Mohammad Reza Nowroozi * , Mohsen Ayati , Hasan Jamshidian , Bentolhoda Rajaei , Faeze Ghasemi
Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran, Phone: +98 21 61192764 , mrnowroozi@tums.ac.ir
Abstract:   (14752 Views)
Background and Aim: We conducted this study to evaluate and compare the sensitivity and specificity of various para-clinic parameters in detecting prostate cancer. Materials and Methods: In this cross-sectional study, 220 patients who underwent prostate biopsies for either high serum PSA level or abnormal digital rectal examination. Sensitivity and specificity of serum PSA, free to total PSA ratio and transrectal ultrasonography findings were calculated. Results: Based on the pathological findings in 220 cases, 25% were diagnosed with prostate cancer. The mean age of patients with prostate cancer was 69.118.6 years. Mean serum PSA level among prostate cancer patients was significantly higher than in other patients (19.517.5 ng/dl vs. 10.58.1 ng/dl) (P=0.003). The sensitivity and specificity of PSA for detecting prostate cancer, considering cut-off value of 4 ng/dl, was 92% and 2%, respectively. Free to total PSA ratio with cut-off value of 10% revealed 82% sensitivity and 17% specificity. Moreover, hypoechoic lesions detected by transrectal ultrasound had a sensitivity and specificity of 34% and 93%, respectively. Conclusion: combination of different PSA related parameters with tranrectal ultrasound findings might increase sensitivity and specificity in detecting prostate cancer and reduce unnecessary biopsies.
Keywords: Prostate cancer, Transrectal high-intensity focused ultrasound, Pathologies, Image-guided biopsy, Prostate-specific antigen
Full-Text [P DF 386 kb]   (2368 Downloads)    
Type of Study: Original | Subject: Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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Mansoor Jamali Zawarei, Mohammad Reza Nowroozi, Mohsen Ayati, Hasan Jamshidian, Bentolhoda Rajaei, Faeze Ghasemi. Sensitivity and specificity of serum PSA, free to total PSA ratio and transrectal ultrasonography findings in prostate cancer detection. pajoohande 2014; 19 (2) :86-90
URL: http://pajoohande.sbmu.ac.ir/article-1-1731-en.html
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Volume 19, Issue 2 (خرداد و تیر 2014) Back to browse issues page
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