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Effect of dietary supplementation with conjugated linoleic acid on bone mineral density, bone metabolism markers and inflammatory markers in healthy post-menopausal women: a randomized double blind placebo controlled trial
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Azadeh Tavakoli Darestani   , Reza Tavakoli Darestani * , Farideh Tahbaz , Farhad Hosseinpanah , Farideh Najafi |
| Associate Professor, Department of Orthopedics, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran , tavakolireza@mihanmail.ir |
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Abstract: (7182 Views) |
| Background and Aim: Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism in experimental animals and cell culture, but there are limited human data available. Materials and Methods: The study consisted of a double-blind, placebo-controlled trial in which 76 healthy post-menopausal women (aged 55.1) were randomly assigned to receive daily either four capsules of CLA G80 containing 3.2 g isomer blend (50:50% cis-9, trans-11:trans-10, cis-12 isomers) or four capsules containing high oleic sunflower oil as placebo for 12 weeks. Urine and blood samples were collected at weeks 0 and 12 and were analyzed for biomarkers of calcium and bone metabolism and inflammatory markers (TNF-α and IL-6). Subjects completed 3-day dietary records during the trial in weeks 0 (baseline), 6, and 12. Results: Supplementation with 3.2 g CLA isomer blend (50:50% cis-9, trans-11:trans-10, cis-12 isomers) for 12 weeks had no significant effects on markers of bone formation (serum osteocalcin, bone-specific alkaline phosphatase) or bone resorption (urine C-telopeptide-related fraction of type 1 collagen degradation products), PTH, urinary calcium, urinary creatinine and CTP to creatinine ratio. Serum interlukine-6 did not change significantly over 12 weeks in postmenopausal women. Conclusion: Under the conditions tested in this double-blind, placebo-controlled trial in postmenopausal women, 3.2 g CLA isomer blend (50:50% cis-9, trans-11:trans-10, cis-12 isomers) did not affect markers of bone metabolism and calcium. |
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| Keywords: Conjugated linoleic acid (CLA), Post-menopausal women, Bone mineral density, IL-6 |
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Full-Text [PDF 493 kb]
(3087 Downloads)
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Type of Study: Original |
Subject:
Medicine
Received: 2017 | Accepted: 2017 | Published: 2017
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